Influence of the amino-terminal sequence on the structure and function of HIV integrase

Influence of the amino-terminal sequence on the structure and function of HIV integrase

Abstract Background Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by the human immunodeficiency virus (HIV). Successful development of ART can be accelerated by accurate structural and biochemical data on targets and their responses to inhibitors. One important ART tar...

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Bibliographic Details
Main Authors: Grant Eilers, Kushol Gupta, Audrey Allen, Jeffrey Zhou, Young Hwang, Michael B. Cory, Frederic D. Bushman, Gregory Van Duyne
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Retrovirology
Subjects:
Integrases
Retroviridae
HIV
X-ray crystallography
Protein structure
Biophysics
Online Access:http://link.springer.com/article/10.1186/s12977-020-00537-x

Internet

http://link.springer.com/article/10.1186/s12977-020-00537-x

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