A Novel Chip for Cyclic Stretch and Intermittent Hypoxia Cell Exposures Mimicking Obstructive Sleep Apnea

A Novel Chip for Cyclic Stretch and Intermittent Hypoxia Cell Exposures Mimicking Obstructive Sleep Apnea

Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), plays a critical role in the pathogenesis of OSA-associated morbidities, especially in the cardiovascular and respiratory systems. Oxidative stress and inflammation induced by IH are suggested as main contributors of end-organ d...

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Bibliographic Details
Main Authors: Noelia Campillo, Ignasi Jorba, Laura Schaedel, Blai Casals, David Gozal, Ramon Farre, Isaac Almendros, Daniel Navajas
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Physiology
Subjects:
obstructive sleep apnea
intermittent hypoxia
hypoxia-inducible factor
lab-on-a-chip
cell stretch
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00319/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00319/full

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