Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: Implications for epileptogenesis

Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: Implications for epileptogenesis

Hippocampal sclerosis, the main pathological sign of chronic temporal lobe epilepsy (TLE), is associated with oxidative injury, altered N-methyl d-aspartate receptor (NMDAR) stoichiometry, and loss of hippocampal neurons. However, the mechanisms that drive the chronic progression of TLE remain elusi...

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Bibliographic Details
Main Authors: Roberto Di Maio, Pier G. Mastroberardino, Xiaoping Hu, Laura M. Montero, J. Timothy Greenamyre
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Neurobiology of Disease
Subjects:
Neuronal excitability
Oxidative stress
ERK signaling
NMDA receptor subunits expression
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002549

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http://www.sciencedirect.com/science/article/pii/S0969996112002549

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