Molecular Dynamics Simulations of Voltage Gated Cation Channels: Insights on Voltage-Sensor Domain Function and Modulation

Since their discovery in the 1950s, the structure and function of voltage gated cation channels (VGCC) has been largely understood thanks to results stemming from electrophysiology, pharmacology, spectroscopy and structural biology. Over the past decade, computational methods such as molecular dynam...

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Bibliographic Details
Main Authors: Lucie eDelemotte, Michael L. Klein, Mounir eTAREK
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00097/full