Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein.

Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein.

The membrane proximal external region (MPER) of the gp41 subunit of the HIV-1 envelope glycoprotein (Env) contains determinants for broadly neutralizing antibodies and has remained an important focus of vaccine design. However, creating an immunogen that elicits broadly neutralizing antibodies to th...

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Bibliographic Details
Main Authors: Russell Vassell, Yong He, Prasad Vennakalanti, Antu K Dey, Min Zhuang, Wei Wang, Yide Sun, Zohar Biron-Sorek, Indresh K Srivastava, Celia C LaBranche, David C Montefiori, Susan W Barnett, Carol D Weiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4472232?pdf=render

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http://europepmc.org/articles/PMC4472232?pdf=render

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