Effect of hypoxia on the expression of genes that encode some IGFBP and CCN proteins in U87 glioma cells depends on IRE1 signaling

Effect of hypoxia on the expression of genes that encode some IGFBP and CCN proteins in U87 glioma cells depends on IRE1 signaling

We have studied hypoxic regulation of the expression of different insulin-like growth factor binding­ protein genes in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1), a central mediator of endoplasmic reticulum stress, which controls cell proliferation and tumor gro...

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Bibliographic Details
Main Authors: O. H. Minchenko, A. P. Kharkova, D. O. Minchenko, L. L. Karbovskyi
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2015-12-01
Series:Ukrainian Biochemical Journal
Subjects:
endoplasmic reticulum stress
glioma cells
hypoxia
IGFBP10/CYR61
IGFBP6
IGFBP7
IGFBP9/NOV
IRE1 inhibition
mRNA expression
WISP1
WISP2
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2015/12/Minchenko_6_15.pdf

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http://ukrbiochemjournal.org/wp-content/uploads/2015/12/Minchenko_6_15.pdf

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