Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish

Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish

Using a zebrafish model of hepatoerythropoietic porphyria (HEP), we identify a previously unknown mechanism underlying heme-mediated regulation of exocrine zymogens. Zebrafish bach1b, nrf2a and mafK are all expressed in the zebrafish exocrine pancreas. Overexpression of bach1b or knockdown of nrf2a...

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Bibliographic Details
Main Authors: Shuqing Zhang, Minrui Xu, Jian Huang, Lili Tang, Yanqing Zhang, Jingyao Wu, Shuo Lin, Han Wang
Format: Article
Language:English
Published: The Company of Biologists 2014-07-01
Series:Disease Models & Mechanisms
Subjects:
Bach1b
Nrf2a
MafK
Heme
Porphyria
Zymogens
Zebrafish
Online Access:http://dmm.biologists.org/content/7/7/837

Internet

http://dmm.biologists.org/content/7/7/837

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