Modulation of bleomycin-induced lung fibrosis by pegylated hyaluronidase and dopamine receptor antagonist in mice.

Modulation of bleomycin-induced lung fibrosis by pegylated hyaluronidase and dopamine receptor antagonist in mice.

Hyaluronidases are groups of enzymes that degrade hyaluronic acid (HA). To stop enzymatic hydrolysis we modified testicular hyaluronidase (HYAL) by activated polyethylene oxide with the help of electron-beam synthesis. As a result we received pegylated hyaluronidase (pegHYAL). Spiperone is a selecti...

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Main Authors: Evgenii Germanovich Skurikhin, Olga Victorovna Pershina, Alena Mikhaylovna Reztsova, Natalia Nikolaevna Ermakova, Ekaterina Sergeevna Khmelevskaya, Vycheslav Andreevich Krupin, Inna Ernestovna Stepanova, Andrew Vladimirovich Artamonov, Andrew Alexandrovich Bekarev, Pavel Gennadjevich Madonov, Alexander Mikhaylovich Dygai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4415936?pdf=render

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http://europepmc.org/articles/PMC4415936?pdf=render

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