Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase

Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase

The tumor microenvironment for epithelial ovarian cancer is complex and rich in bioactive molecules that modulate cell-cell interactions and stimulate numerous signal transduction cascades. These signals ultimately modulate all aspects of tumor behavior including progression, metastasis and therapeu...

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Bibliographic Details
Main Authors: Laurie G. Hudson, Jennifer M. Gillette, Huining Kang, Melanie R. Rivera, Angela Wandinger-Ness
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
Rho-GTPase
Rac1
guanine nucleotide exchange factors (GEFs)
GTPase activating proteins (GAPs)
oncogene
oncoprotein
ovarian cancer
tumor microenvironment
bone niche
therapeutic targeting
Online Access:http://www.mdpi.com/2072-6694/10/10/358

Internet

http://www.mdpi.com/2072-6694/10/10/358

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