RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?

RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?

Tylosis with esophageal cancer syndrome (TOC) is a rare autosomal dominant proliferative skin disease caused by missense mutations in the rhomboid 5 homolog 2 (RHBDF2) gene. TOC is characterized by thickening of the skin in the palms and feet and is strongly linked with the development of esophageal...

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Bibliographic Details
Main Authors: Vishnu Hosur, Michelle L. Farley, Benjamin E. Low, Lisa M. Burzenski, Leonard D. Shultz, Michael V. Wiles
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Genetics
Subjects:
Rhbdf2
TOC
EGFR
ADAM17/TACE
AREG
CRISPR-Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00233/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00233/full

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