Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle

Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle

Summary: The major objective of this study was to understand the molecular basis of how sarcolipin uncoupling of SERCA regulates muscle oxidative metabolism. Using genetically engineered sarcolipin (SLN) mouse models and primary muscle cells, we demonstrate that SLN plays a crucial role in mitochond...

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Bibliographic Details
Main Authors: Santosh K. Maurya, Jose L. Herrera, Sanjaya K. Sahoo, Felipe C.G. Reis, Rick B. Vega, Daniel P. Kelly, Muthu Periasamy
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471831307X

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http://www.sciencedirect.com/science/article/pii/S221112471831307X

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