Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells.

Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells.

Syndecan-1 forms complexes with growth factors and their cognate receptors in the cell membrane. We have previously reported a tubulin-mediated translocation of syndecan-1 to the nucleus. The transport route and functional significance of nuclear syndecan-1 is still incompletely understood. Here we...

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Bibliographic Details
Main Authors: Fang Zong, Eleni Fthenou, Nina Wolmer, Péter Hollósi, Ilona Kovalszky, László Szilák, Carolin Mogler, Gustav Nilsonne, Georgios Tzanakakis, Katalin Dobra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2750749?pdf=render

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http://europepmc.org/articles/PMC2750749?pdf=render

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