WIP1 Inhibition by GSK2830371 Potentiates HDM201 through Enhanced p53 Phosphorylation and Activation in Liver Adenocarcinoma Cells

WIP1 Inhibition by GSK2830371 Potentiates HDM201 through Enhanced p53 Phosphorylation and Activation in Liver Adenocarcinoma Cells

Background: Intrahepatic cholangiocarcinoma (iCCA) is an adenocarcinoma arising from the intrahepatic bile duct. It is the second most common primary liver cancer and has a poor prognosis. Activation of p53 by targeting its negative regulators, <i>MDM2</i> and <i>WIP1</i>, is...

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Bibliographic Details
Main Authors: Chiao-En Wu, Chen-Yang Huang, Chiao-Ping Chen, Yi-Ru Pan, John Wen-Cheng Chang, Jen-Shi Chen, Chun-Nan Yeh, John Lunec
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
HDM201
GSK2830371
MDM2
WIP1
p53
cholangiocarcinoma
Online Access:https://www.mdpi.com/2072-6694/13/15/3876

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https://www.mdpi.com/2072-6694/13/15/3876

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