Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes. ER calcium depletion robustly activates the unfolded protein response (UPR). However, it is...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-12-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/62601 |