Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes. ER calcium depletion robustly activates the unfolded protein response (UPR). However, it is...

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Bibliographic Details
Main Authors: Steffen Preissler, Claudia Rato, Yahui Yan, Luke A Perera, Aron Czako, David Ron
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
BiP
Online Access:https://elifesciences.org/articles/62601