The Study of NADPH-Dependent Flavoenzyme-Catalyzed Reduction of Benzo[1,2-c]1,2,5-oxadiazole N-Oxides (Benzofuroxans)

The Study of NADPH-Dependent Flavoenzyme-Catalyzed Reduction of Benzo[1,2-c]1,2,5-oxadiazole N-Oxides (Benzofuroxans)

The enzymatic reactivity of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxides (benzofuroxans; BFXs) towards mammalian single-electron transferring NADPH:cytochrome P-450 reductase (P-450R) and two-electron (hydride) transferring NAD(P)H:quinone oxidoreductase (NQO1) was examined in this work. Since...

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Bibliographic Details
Main Authors: Jonas Šarlauskas, Lina Misevičienė, Audronė Marozienė, Laimonas Karvelis, Jonita Stankevičiūtė, Kastis Krikštopaitis, Narimantas Čėnas, Aleksey Yantsevich, Audrius Laurynėnas, Žilvinas Anusevičius
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
benzofuroxan
flavoenzyme
redox-cycling
bioreductive conversion
quantitative structure activity relationship
quantum mechanical calculation
DFT
Online Access:http://www.mdpi.com/1422-0067/15/12/23307

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http://www.mdpi.com/1422-0067/15/12/23307

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