Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis

Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis

The phencyclidine compound MK-801 can induce psychosis with symptoms which closely resemble those observed in an acute schizophrenic episode. Here we used an in vitro model of psychosis after systemic administration of MK-801. We found that kainate-induced gamma frequency field oscillations in anima...

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Bibliographic Details
Main Authors: Colin Kehrer, Tamar Dugladze, Nino Maziashvili, Anna Wójtowicz, Dietmar Schmitz, Uwe Heinemann, Tengis Gloveli
Format: Article
Language:English
Published: Elsevier 2007-03-01
Series:Neurobiology of Disease
Subjects:
Schizophrenia
Network oscillations
MK-801
Hippocampus
IPSPs
Na+-K+-pump
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002890

Internet

http://www.sciencedirect.com/science/article/pii/S0969996106002890

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