Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work
Lactate, the conjugate base of lactic acid occurring in aqueous biological fluids, has been derided as a dead-end waste product of anaerobic metabolism. Catalyzed by the near-equilibrium enzyme lactate dehydrogenase (LDH), the reduction of pyruvate to lactate is thought to serve to regenerate the NA...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00366/full |