Adenosine A<sub>2A</sub> Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease

Adenosine A<sub>2A</sub> Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease

(1) Background. <i>N</i>-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer’s disease (AD), is expressed in both neurons and glial cells. The aim of this paper was to assess whether the adenosine A<sub>2A</sub>...

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Bibliographic Details
Main Authors: Rafael Franco, Rafael Rivas-Santisteban, Mireia Casanovas, Alejandro Lillo, Carlos A. Saura, Gemma Navarro
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
G-protein-coupled receptors
functional selectivity
microglia
neuroprotection
cognition
signaling
Online Access:https://www.mdpi.com/2073-4409/9/5/1075

Internet

https://www.mdpi.com/2073-4409/9/5/1075

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