Polycystin-1 Downregulation Induced Vascular Smooth Muscle Cells Phenotypic Alteration and Extracellular Matrix Remodeling in Thoracic Aortic Dissection

Polycystin-1 Downregulation Induced Vascular Smooth Muscle Cells Phenotypic Alteration and Extracellular Matrix Remodeling in Thoracic Aortic Dissection

ObjectivePolycystin-1 (PC-1) is a protein encoded by the gene of polycystic kidney disease-1 (PKD-1). This study was designed to investigate the regulatory mechanisms of PC-1 on phenotypes of aortic vascular smooth muscle cells (VSMCs) and functions of extracellular matrix (ECM) in thoracic aortic d...

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Bibliographic Details
Main Authors: Jing Zhang, Fei Liu, Yu-bin He, Wei Zhang, Wen-rui Ma, Jie Xing, Li-xin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
polycystin-1
vascular smooth muscle cells
phenotype
aortic dissection
extracellular matrix
rapamycin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.548055/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.548055/full

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