Constitutively Active Akt1 Cooperates with KRasG12D to Accelerate In Vivo Pancreatic Tumor Onset and Progression

Constitutively Active Akt1 Cooperates with KRasG12D to Accelerate In Vivo Pancreatic Tumor Onset and Progression

BACKGROUND AND AIMS: Pancreatic adenocarcinoma is a deadly disease characterized by metastatic progression and resistance to conventional therapeutics. Mutation of KRAS is the most frequent early event in pancreatic tumor progression. AKT isoforms are frequently activated in pancreatic cancer, and...

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Bibliographic Details
Main Authors: Toya M. Albury, Veethika Pandey, Sarah B. Gitto, Lisette Dominguez, Lina P. Spinel, Jacqueline Talarchek, Andres J. Klein-Szanto, Joseph R. Testa, Deborah A. Altomare
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614001961

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http://www.sciencedirect.com/science/article/pii/S1476558614001961

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