Tmub1 Suppresses Hepatocellular Carcinoma by Promoting the Ubiquitination of ΔNp63 Isoforms

Tmub1 Suppresses Hepatocellular Carcinoma by Promoting the Ubiquitination of ΔNp63 Isoforms

Transmembrane and ubiquitin-like domain-containing 1 (Tmub1) inhibits hepatocyte proliferation during liver regeneration, but its role in hepatocellular carcinoma (HCC) has yet to be revealed. In this study, we show that the levels of Tmub1 were significantly lower in HCC tissues and cells than they...

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Bibliographic Details
Main Authors: Hangwei Fu, Yida Zhang, Junying Chen, Bo Zhou, Geng Chen, Ping Chen
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
transmembrane and ubiquitin-like domain containing 1 protein
hepatocellular carcinoma
tumor suppressor
cell apoptosis
tumor protein 63
post-translational modification
Online Access:http://www.sciencedirect.com/science/article/pii/S237277052030084X

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http://www.sciencedirect.com/science/article/pii/S237277052030084X

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