Molecular Targets of TRAIL-Sensitizing Agents in Colorectal Cancer

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily, interacts with its functional death receptors (DRs) and induces apoptosis in a wide range of cancer cell types. Therefore, TRAIL has been considered as an attractive agent for cancer therapy. Howe...

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Bibliographic Details
Main Authors: Giovanni Monteleone, Francesco Pallone, Carmine Stolfi
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:International Journal of Molecular Sciences
Subjects:
DR4
DR5
p53
Online Access:http://www.mdpi.com/1422-0067/13/7/7886