Astrocytes Are Required for Oligodendrocyte Survival and Maintenance of Myelin Compaction and Integrity

Astrocytes Are Required for Oligodendrocyte Survival and Maintenance of Myelin Compaction and Integrity

Astrocytes have been implicated in regulating oligodendrocyte development and myelination in vitro, although their functions in vivo remain less well defined. Using a novel approach to locally ablate GFAP+ astrocytes, we demonstrate that astrocytes are required for normal CNS myelin compaction durin...

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Bibliographic Details
Main Authors: Reshmi Tognatta, Molly T. Karl, Sharyl L. Fyffe-Maricich, Anastas Popratiloff, Eric D. Garrison, Jessica K. Schenck, Mohammad Abu-Rub, Robert H. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
astrocytes
myelin maintenance
glutamate
NMDA receptors
electron microscopy
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00074/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00074/full

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