Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress

Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress

This study was designed to investigate the effect of increased levels of HO-1 on hypertension exacerbated by diabetes. Diabetic spontaneously hypertensive rat (SHR) and WKY (control) animals were treated with streptozotocin (STZ) to induce diabetes and stannous chloride (SnCl2) to upregulate HO-1. T...

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Bibliographic Details
Main Authors: Jian Cao, George Drummond, Kazuyoshi Inoue, Shinji Omura, Komal Sodhi, Xiao Ying Li
Format: Article
Language:English
Published: MDPI AG 2008-12-01
Series:International Journal of Molecular Sciences
Subjects:
Heme oxygenase
hypertension
diabetes
adiponectin
oxidative stress
apoptosis
Online Access:http://www.mdpi.com/1422-0067/9/12/2388/

Internet

http://www.mdpi.com/1422-0067/9/12/2388/

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