Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression. To elucidate the role of endogenous murine tau in a model with both plaques and tangles, we d...

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Bibliographic Details
Main Authors: David Baglietto-Vargas, Masashi Kitazawa, Elaine J. Le, Tatiana Estrada-Hernandez, Carlos J. Rodriguez-Ortiz, Rodrigo Medeiros, Kim N. Green, Frank M. LaFerla
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Tau
Hippocampus
3xTg-AD mice
Neurofibrillary tangles
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002945

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http://www.sciencedirect.com/science/article/pii/S0969996113002945

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