Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis

Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis

Oxyresveratrol (ORes, trans-2,4,3′,5′-tetrahydroxy stilbene) naturally exists in mulberry, grapes, peanuts and other plants. It belongs to stilbene polyphenolic family and has an extra hydroxyl group at 2-position comparing with resveratrol (Res). Hence, ORes has stronger antioxidant activity than r...

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Bibliographic Details
Main Authors: Guliang Yang, Jianfeng Zhan, Yiwen Yang, Li Yuan, Peilei Wang, Chi-Tang Ho, Shiming Li
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-01-01
Series:Food Science and Human Wellness
Subjects:
Oxyresveratrol
Hepatic fibrosis
Oxidative stress
TGF-β/Smad/ERK signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2213453020301920

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http://www.sciencedirect.com/science/article/pii/S2213453020301920

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