p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates.

p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates.

The cell cycle inhibitor p21CDKN1A was previously found to interact directly with DNA nick-sensor poly(ADP-ribose) polymerase-1 (PARP-1) and to promote base excision repair (BER). However, the molecular mechanism responsible for this BER-related association of p21 with PARP-1 remains to be clarified...

Full description

Bibliographic Details
Main Authors: Ilaria Dutto, Maria Sukhanova, Micol Tillhon, Ornella Cazzalini, Lucia A Stivala, A Ivana Scovassi, Olga Lavrik, Ennio Prosperi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4701469?pdf=render

Internet

http://europepmc.org/articles/PMC4701469?pdf=render

Similar Items