Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.

Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.

Protein-tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed PTP that is anchored to the endoplasmic reticulum (ER). PTP1B dephosphorylates activated receptor tyrosine kinases after endocytosis, as they transit past the ER. However, PTP1B also can access some plasma membrane (PM)-bound substr...

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Bibliographic Details
Main Authors: Fawaz G Haj, Ola Sabet, Ali Kinkhabwala, Sabine Wimmer-Kleikamp, Vassilis Roukos, Hong-Mei Han, Markus Grabenbauer, Martin Bierbaum, Claude Antony, Benjamin G Neel, Philippe I Bastiaens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360045?pdf=render

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http://europepmc.org/articles/PMC3360045?pdf=render

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