DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

Alterations in cerebral cortex connectivity lead to intellectual disability and in Down syndrome, this is associated with a deficit in cortical neurons that arises during prenatal development. However, the pathogenic mechanisms that cause this deficit have not yet been defined. Here we show that the...

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Bibliographic Details
Main Authors: Sònia Najas, Juan Arranz, Pamela A. Lochhead, Anne L. Ashford, David Oxley, Jean M. Delabar, Simon J. Cook, María José Barallobre, Maria L. Arbonés
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:EBioMedicine
Subjects:
Cell cycle regulation
DYRK kinases
Cerebral cortex development
Trisomy 21
Neurodevelopmental disorders
Intellectual disability
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641500033X

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http://www.sciencedirect.com/science/article/pii/S235239641500033X

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