Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications
Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stabilit...
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doaj-2e27d91ac2144a458f267f120aef4e162020-11-25T01:07:46ZengMDPI AGMolecules1420-30492017-05-0122578210.3390/molecules22050782molecules22050782Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic ApplicationsWenzhang Cha0Rengen Fan1Yufeng Miao2Yong Zhou3Chenglin Qin4Xiangxiang Shan5Xinqiang Wan6Jinbo Li7Department of General Surgery, Yancheng City No. 1 People’s Hospital, Yancheng 224001, ChinaDepartment of General Surgery, Yancheng City No. 1 People’s Hospital, Yancheng 224001, ChinaDepartment of Medical Oncology, Yancheng City No. 1 People’s Hospital, Yancheng 224001, ChinaDepartment of General Surgery, Yancheng City No. 1 People’s Hospital, Yancheng 224001, ChinaDepartment of General Surgery, Yancheng City No. 1 People’s Hospital, Yancheng 224001, ChinaDepartment of Gerontology, Yancheng City No. 1 People’s Hospital, Yancheng 224001, ChinaDepartment of Clinical Medicine, Nantong University Xinglin College, Nantong 226000, ChinaSchool of Chemistry and Chemical Engineering, Nanjing Unviersity, Nanjing 210023, ChinaNucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stability have greatly hindered the applications of nucleic acids in biomedicine. To address these issues, associate carriers that can encapsulate and protect nucleic acids are urgently required. Mesoporous silica nanoparticles (MSNs or MSNPs), which are nanomaterials with excellent biocompatibility, large surface area for functionalization, and tunable pore size for encapsulating different cargos, are emerging as novel and ideal biomaterials for different biomedical applications. In this review paper, we focus on the applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutic treatments. General strategies for the preparation of nucleic acid-MSN complexes will be firstly introduced, followed by a summary of recent applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutics.http://www.mdpi.com/1420-3049/22/5/782mesoporous silica nanoparticlesnucleic acidsdrug deliverytherapeutics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenzhang Cha Rengen Fan Yufeng Miao Yong Zhou Chenglin Qin Xiangxiang Shan Xinqiang Wan Jinbo Li |
spellingShingle |
Wenzhang Cha Rengen Fan Yufeng Miao Yong Zhou Chenglin Qin Xiangxiang Shan Xinqiang Wan Jinbo Li Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications Molecules mesoporous silica nanoparticles nucleic acids drug delivery therapeutics |
author_facet |
Wenzhang Cha Rengen Fan Yufeng Miao Yong Zhou Chenglin Qin Xiangxiang Shan Xinqiang Wan Jinbo Li |
author_sort |
Wenzhang Cha |
title |
Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications |
title_short |
Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications |
title_full |
Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications |
title_fullStr |
Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications |
title_full_unstemmed |
Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications |
title_sort |
mesoporous silica nanoparticles as carriers for intracellular delivery of nucleic acids and subsequent therapeutic applications |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-05-01 |
description |
Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stability have greatly hindered the applications of nucleic acids in biomedicine. To address these issues, associate carriers that can encapsulate and protect nucleic acids are urgently required. Mesoporous silica nanoparticles (MSNs or MSNPs), which are nanomaterials with excellent biocompatibility, large surface area for functionalization, and tunable pore size for encapsulating different cargos, are emerging as novel and ideal biomaterials for different biomedical applications. In this review paper, we focus on the applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutic treatments. General strategies for the preparation of nucleic acid-MSN complexes will be firstly introduced, followed by a summary of recent applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutics. |
topic |
mesoporous silica nanoparticles nucleic acids drug delivery therapeutics |
url |
http://www.mdpi.com/1420-3049/22/5/782 |
work_keys_str_mv |
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