Mutations primarily alter the inclusion of alternatively spliced exons
Genetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of alternatively spliced exons, consistent with the concept that altered splicing might be a common mechanism by which mutations cause disease. Howev...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/59959 |