Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.

Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.

Osteoclasts are the body's sole bone resorbing cells. Cytokines produced by pro-inflammatory effector T-cells (T(EFF)) increase bone resorption by osteoclasts. Prolonged exposure to the T(EFF) produced cytokines leads to bone erosion diseases such as osteoporosis and rheumatoid arthritis. The c...

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Bibliographic Details
Main Authors: Zachary S Buchwald, Jennifer R Kiesel, Richard DiPaolo, Meghana S Pagadala, Rajeev Aurora
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3368916?pdf=render

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http://europepmc.org/articles/PMC3368916?pdf=render

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