Development of two distinct dendritic-like APCs in the context of splenic stroma

Murine splenic stroma has been found to provide an in vitro niche for hematopoiesis of dendritic-like APCs (APC). Two distinct cell types have been characterised. The novel ‘L-DC’ subset, has cross presenting capacity leading to activation of CD8+ T cells, but do not activate CD4+ T cells consistent...

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Bibliographic Details
Main Authors: Pravin ePeriasamy, Sawang ePetvises, Helen eO'Neill
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00073/full