SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway

SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway

Objective: The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner. Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer. Nevertheless, the mechanistic details of how...

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Bibliographic Details
Main Authors: Yue Yuan*, Yanling Fan*, Zicong Gao, Xuan Sun, He Zhang, Zhiyong Wang, Yanfen Cui, Weijie Song, Zhaosong Wang, Fei Zhang, Ruifang Niu
Format: Article
Language:English
Published: China Anti-Cancer Association 2020-08-01
Series:Cancer Biology & Medicine
Subjects:
shp2
breast cancer
proliferation
cyclin d1
gsk3β
pi3k/akt
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1678

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1678

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