The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes

The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes

T cell receptor (TCR) signaling influences multiple aspects of CD4+ and CD8+ T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines...

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Bibliographic Details
Main Authors: Matthew Clark, Charles J. Kroger, Qi Ke, Roland M. Tisch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
diabetes
immunoregulation
T cell receptor (TCR) signaling
T cell differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.615371/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.615371/full

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