Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

Differentiating neurons have an increased requirement for copper than their precursors, but the mechanism of altered copper homoeostasis is not known. Here, Hatori et al. show that neuronal differentiation is accompanied by an increased flux of copper through the secretory pathway, increasing supply...

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Bibliographic Details
Main Authors: Yuta Hatori, Ye Yan, Katharina Schmidt, Eri Furukawa, Nesrin M. Hasan, Nan Yang, Chin-Nung Liu, Shanthini Sockanathan, Svetlana Lutsenko
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10640