Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques

Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques

Chimeric antigen receptor (CAR) T cell therapies are being investigated as potential HIV cures and designed to target HIV reservoirs. Monoclonal antibodies (mAbs) targeting the simian immunodeficiency virus (SIV) envelope allowed us to investigate the potency of single-chain variable fragment (scFv)...

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Bibliographic Details
Main Authors: Françoise Haeseleer, Yoshinori Fukazawa, Haesun Park, Benjamin Varco-Merth, Blake J. Rust, Jeremy V. Smedley, Karsten Eichholz, Christopher W. Peterson, Rosemarie Mason, Hans-Peter Kiem, Mario Roederer, Louis J. Picker, Afam A. Okoye, Lawrence Corey
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CAR T cells
HIV
SIV
infectious diseases
humoral immune response
autologous cell therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001108

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http://www.sciencedirect.com/science/article/pii/S2329050121001108

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