First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

Abstract Background Efforts to develop suitable positron emission tomography (PET) tracers for the ion channel site of human N-methyl-d-aspartate (NMDA) receptors have had limited success. [18F]PK-209 is a GMOM derivative that binds to the intrachannel phencyclidine site with high affinity and selec...

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Bibliographic Details
Main Authors: Jasper van der Aart, Sandeep S. V. Golla, Marieke van der Pluijm, Lothar A. Schwarte, Robert C. Schuit, Pieter J. Klein, Athanasios Metaxas, Albert D. Windhorst, Ronald Boellaard, Adriaan A. Lammertsma, Bart N. M. van Berckel
Format: Article
Language:English
Published: SpringerOpen 2018-07-01
Series:EJNMMI Research
Subjects:
PET
NMDA
Glutamate
[18F]PK-209
Ketamine
Online Access:http://link.springer.com/article/10.1186/s13550-018-0424-2

Internet

http://link.springer.com/article/10.1186/s13550-018-0424-2

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