An in vitro Perfused Macroencapsulation Device to Study Hemocompatibility and Survival of Islet-Like Cell Clusters

An in vitro Perfused Macroencapsulation Device to Study Hemocompatibility and Survival of Islet-Like Cell Clusters

Transplantation of hydrogel-encapsulated pancreatic islets is a promising long-term treatment for type 1 diabetes that restores blood glucose regulation while providing graft immunoprotection. Most human-scale islet encapsulation devices that rely solely on diffusion fail to provide sufficient surfa...

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Bibliographic Details
Main Authors: Stephanie A. Fernandez, Lisa Danielczak, Gabrielle Gauvin-Rossignol, Craig Hasilo, André Bégin-Drolet, Jean Ruel, Steven Paraskevas, Richard L. Leask, Corinne A. Hoesli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
type 1 diabetes
alginate-based encapsulation
pancreatic islet hypoxia
perfused vascular prosthesis
convective mass transport
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.674125/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.674125/full

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