SZR-104, a Novel Kynurenic Acid Analogue with High Permeability Through the Blood–Brain Barrier

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability Through the Blood–Brain Barrier

By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the blood–brain barrier. One possibility to overco...

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Bibliographic Details
Main Authors: Kinga Molnár, Bálint Lőrinczi, Csilla Fazakas, István Szatmári, Ferenc Fülöp, Noémi Kmetykó, Róbert Berkecz, István Ilisz, István A. A. Krizbai, Imola Wilhelm, László Vécsei
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
aminoalkylated amide derivatives
blood–brain barrier (BBB)
in vitro model
kynurenic acid (KYNA), permeability
SZR-104
Online Access:https://www.mdpi.com/1999-4923/13/1/61

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https://www.mdpi.com/1999-4923/13/1/61

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