Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment

Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment

Thrombospondin-1 (TSP-1) is a potent endogenous inhibitor of both physiological and pathological angiogenesis, widely studied as a target in drug development for treating cancer. Several studies performed in the cardiovascular field on TSP-1 are contradictory, the role of TSP-1 in the physiopatholog...

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Bibliographic Details
Main Authors: Valentina Buda, Minodora Andor, Lucian Petrescu, Carmen Cristescu, Dana Emilia Baibata, Mirela Voicu, Melania Munteanu, Ioana Citu, Calin Muntean, Octavian Cretu, Mirela Cleopatra Tomescu
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:International Journal of Molecular Sciences
Subjects:
TSP-1
thrombospondin-1
endothelial dysfunction
essential arterial hypertension
perindopril
antihypertensive drugs
anti-inflammatory
anti-proliferative
angiotensin-converting enzyme (ACE) inhibitors
Online Access:http://www.mdpi.com/1422-0067/18/2/348

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http://www.mdpi.com/1422-0067/18/2/348

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