Small Molecule Compounds Identified from Mixture-Based Library Inhibit Binding between <i>Plasmodium falciparum</i> Infected Erythrocytes and Endothelial Receptor ICAM-1

Small Molecule Compounds Identified from Mixture-Based Library Inhibit Binding between <i>Plasmodium falciparum</i> Infected Erythrocytes and Endothelial Receptor ICAM-1

Specific adhesion of <i>P. falciparum</i> parasite-infected erythrocytes (IE) in deep vascular beds can result in severe complications, such as cerebral malaria, placental malaria, respiratory distress, and severe anemia. Cerebral malaria and severe malaria syndromes were associated prev...

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Bibliographic Details
Main Authors: Olga Chesnokov, Pimnitah Visitdesotrakul, Komal Kalani, Adel Nefzi, Andrew V. Oleinikov
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
<i>P. falciparum</i>
severe and cerebral malaria
small molecule inhibitors
combinatorial chemistry
mixture-based libraries
drug discovery
Online Access:https://www.mdpi.com/1422-0067/22/11/5659

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https://www.mdpi.com/1422-0067/22/11/5659

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