Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress

Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress

The class III NAD+ dependent deacetylases-sirtuins (SIRTs) link transcriptional regulation to DNA damage response and reactive oxygen species generation thereby modulating a wide range of cellular signaling pathways. Here, the contribution of SIRT1, SIRT3, and SIRT5 in the regulation of cellular fat...

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Bibliographic Details
Main Authors: Richa Garva, Chutamas Thepmalee, Umpa Yasamut, Sangkab Sudsaward, Alice Guazzelli, Ramkumar Rajendran, Nopprarat Tongmuang, Sasiprapa Khunchai, Parisa Meysami, Thawornchai Limjindaporn, Pa-thai Yenchitsomanus, Luciano Mutti, Marija Krstic-Demonacos, Constantinos Demonacos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
autophagy
transcription
sirtuins
beclin-1
LC3
mesothelioma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00949/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00949/full

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