Continuous Release of Tumor-Derived Factors Improves the Modeling of Cachexia in Muscle Cell Culture

Continuous Release of Tumor-Derived Factors Improves the Modeling of Cachexia in Muscle Cell Culture

Cachexia is strongly associated with a poor prognosis in cancer patients but the biological trigger is unknown and therefore no therapeutics exist. The loss of skeletal muscle is the most deleterious aspect of cachexia and it appears to depend on secretions from tumor cells. Models for studying wast...

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Bibliographic Details
Main Authors: Robert W. Jackman, Jess Floro, Rei Yoshimine, Brian Zitin, Maythita Eiampikul, Khalid El-Jack, Danielle N. Seto, Susan C. Kandarian
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Physiology
Subjects:
muscle atrophy
myotubes
LIF
muscle wasting
C2C12
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2017.00738/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2017.00738/full

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