Peripheral IgE Repertoires of Healthy Donors Carry Moderate Mutation Loads and Do Not Overlap With Other Isotypes

Peripheral IgE Repertoires of Healthy Donors Carry Moderate Mutation Loads and Do Not Overlap With Other Isotypes

IgE-mediated allergic disease represents an increasing health problem. Although numerous studies have investigated IgE sequences in allergic patients, little information is available on the healthy IgE repertoire. IgM, IgG, IgA, and IgE transcripts from peripheral blood B cells of five healthy, non-...

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Bibliographic Details
Main Authors: Marvyn T. Koning, Ignis J. M. Trollmann, Cornelis A. M. van Bergen, Diego Alvarez Saravia, Marcelo A. Navarrete, Szymon M. Kiełbasa, Hendrik Veelken
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
affinity maturation
allergy
B-cell receptor
class switching
IgE
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01543/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01543/full

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