Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients

Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients

The omentum is enriched with pro-inflammatory effector memory CD8+ T cells in patients with the obesity-associated malignancy, esophagogastric adenocarcinoma (EAC) and we have identified the chemokine macrophage inflammatory protein-1alpha as a key player in their active migration to this inflamed t...

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Bibliographic Details
Main Authors: Melissa J. Conroy, Stephen G. Maher, Ashanty M. Melo, Suzanne L. Doyle, Emma Foley, John V. Reynolds, Aideen Long, Joanne Lysaght
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
fractalkine
CX3CR1
T cells
obesity
upper gastrointestinal cancer
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01867/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01867/full

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