Neuronal CXCL10/CXCR3 Axis Mediates the Induction of Cerebral Hyperexcitability by Peripheral Viral Challenge

Neuronal CXCL10/CXCR3 Axis Mediates the Induction of Cerebral Hyperexcitability by Peripheral Viral Challenge

Peripheral infections can potently exacerbate neuropathological conditions, though the underlying mechanisms are poorly understood. We have previously demonstrated that intraperitoneal (i.p.) injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces a robust generation of CXCL10 ch...

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Bibliographic Details
Main Authors: Tiffany J. Petrisko, Jenna Bloemer, Priyanka D. Pinky, Sriraja Srinivas, Ryan T. Heslin, Yifeng Du, Sharay E. Setti, Hao Hong, Vishnu Suppiramaniam, Gregory W. Konat, Miranda N. Reed
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Neuroscience
Subjects:
acute phase response
hyperexcitability
polyinosinic-polycytidylic acid
CXCL10
CXCR3
synaptic transmission
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00220/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00220/full

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