Minimizing Ischemia Reperfusion Injury in Xenotransplantation

Minimizing Ischemia Reperfusion Injury in Xenotransplantation

The recent dramatic advances in preventing “initial xenograft dysfunction” in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular,...

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Bibliographic Details
Main Authors: Parth M. Patel, Margaret R. Connolly, Taylor M. Coe, Anthony Calhoun, Franziska Pollok, James F. Markmann, Lars Burdorf, Agnes Azimzadeh, Joren C. Madsen, Richard N. Pierson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
xenotranplantation
ischemia reperfusion (I/R) injury
ex vivo perfusion
initial xenograft dysfunction
ischemia reperfusion injury mechanisms
ischemia reperfusion injury minimization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.681504/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.681504/full

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