Heterocycles 36. Single-Walled Carbon Nanotubes-Bound N,N-Diethyl Ethanolamine as Mild and Efficient Racemisation Agent in the Enzymatic DKR of 2-Arylthiazol-4-yl-alanines

Heterocycles 36. Single-Walled Carbon Nanotubes-Bound N,N-Diethyl Ethanolamine as Mild and Efficient Racemisation Agent in the Enzymatic DKR of 2-Arylthiazol-4-yl-alanines

In this paper we describe the chemoenzymatic synthesis of enantiopure l-2-arylthiazol-4-yl alanines starting from their racemic N-acetyl derivatives; by combining the lipase-catalysed dynamic kinetic resolution of oxazol-5(4H)-ones with a chemical and an enzymatic enantioselective hydrolytic step af...

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Bibliographic Details
Main Authors: Denisa Leonte, László Csaba Bencze, Csaba Paizs, Monica Ioana Toşa, Valentin Zaharia, Florin Dan Irimie
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
hydrolases
dynamic kinetic resolution
racemisation agent
l-α-amino acids
thiazole
Online Access:http://www.mdpi.com/1420-3049/21/1/25

Internet

http://www.mdpi.com/1420-3049/21/1/25

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