DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression

DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression

Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA3). Herein, we demonstrate that significant amounts of DXA3 are rapidly attached to phosphatidylethanolamine (PE) forming four esterified eicosanoids, 16:0p, 18:0p, 18:1p and 18:0a/DXA3-PEs that can activate ne...

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Bibliographic Details
Main Authors: Maceler Aldrovandi, Christine Hinz, Sarah N. Lauder, Helen Podmore, Martin Hornshaw, David A. Slatter, Victoria J. Tyrrell, Stephen R. Clark, Lawrence J. Marnett, Peter W. Collins, Robert C. Murphy, Valerie B. O’Donnell
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716304724

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http://www.sciencedirect.com/science/article/pii/S2213231716304724

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